Cortical and subcortical changes in typically developing preadolescent children

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Cortical and subcortical changes in typically developing preadolescent children.

There is evidence that abnormal cerebral development during childhood is a risk factor for various cognitive and psychiatric disorders. There is not, however, sufficient normative data available on large samples of typically developing children, especially within the narrow preadolescent age range. We analyzed high resolution MRI images from 126 normally developing children between ages 6 and 1...

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The first phase of major neuronal rearrangements in the brain takes place during the prenatal period. While the brain continues maturation throughout childhood, a critical second phase of synaptic overproduction and elimination takes place during the preadolescent period. Despite the importance of this developmental phase, few studies have evaluated neural changes taking place during this perio...

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Pronoun reversals occur when a pronoun is incorrectly mapped to the wrong referent. For example, when a child says, “You eat the cookie!” and intended to state that he is eating a cookie. Children with Autism Spectrum Disorder, ASD, are known to be frequent reversers, but their development of these reversals; for example, incidence rate and endpoint, is still unknown. In this study, children in...

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CONTEXT Just as typical development of anatomical asymmetries in the human brain has been linked with normal lateralization of motor and cognitive functions, disruption of asymmetry has been implicated in the pathogenesis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). No study has examined the development of cortical asymmetry using longitudinal neuroan...

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ژورنال

عنوان ژورنال: Brain Research

سال: 2011

ISSN: 0006-8993

DOI: 10.1016/j.brainres.2011.05.018